{"id":5841,"date":"2021-05-05T17:27:27","date_gmt":"2021-05-05T10:27:27","guid":{"rendered":"https:\/\/www.primotrading.co.th\/?p=5841"},"modified":"2021-05-05T17:27:27","modified_gmt":"2021-05-05T10:27:27","slug":"top-short-term-and-long-term-immune-health-ingredients","status":"publish","type":"post","link":"https:\/\/www.primotrading.co.th\/th\/articles-th\/top-short-term-and-long-term-immune-health-ingredients\/","title":{"rendered":"Top short-term and long-term immune health ingredients"},"content":{"rendered":"<p>[vc_row][vc_column][vc_custom_heading text=&#8221;Top short-term and long-term immune health ingredients&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<strong>Formulators can choose from a range of short-term and long-term ingredients when it comes to immune health support.<\/strong>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]When it comes to immune health, it is essential for brand owners to determine what type of immune support they\u2019re trying to provide through a formulation.<\/p>\n<p>Examples include:[\/vc_column_text][vc_column_text]<strong>a. A person thinks they may be coming down with a cold or flu<\/strong>\u2014they need something to stimulate immune response.<\/p>\n<p><strong>b. A person has a chronic immune weakness such as allergies, colds, flu, etc.\u00a0<\/strong>\u2014they need something for long-term support of immune functionality.<\/p>\n<p><strong>c. A person has an autoimmune or overactive immune response<\/strong>\u2014they need something to modulate or even downregulate immune function.<\/p>\n<p><strong>d. A person has chronic inflammation such as joint pain, cardiovascular problems, etc<\/strong>.\u2014they need something to support the body\u2019s response to inflammation (inflammation is an initial response by the immune system to potential harm from things such as physical trauma, bacteria, virus, etc.).[\/vc_column_text][vc_column_text]Of these, supplement manufacturers should keep in mind that the first two are what most consumers think about when a product is touted as an immune health\u00a0product. They are either sick and need acute help to stimulate the immune system, or they\u2019re looking for long-term benefits to support the immune system and its functionality.\u00a0The following examples of both short- and long-term nutraceutical ingredients for immune health are but a few of the numerous immune support ingredients with scientific substantiation.[\/vc_column_text][vc_column_text]<\/p>\n<h3>Short term<\/h3>\n<ul>\n<li><strong>Vitamin C<\/strong>\u00a0acts by increasing lymphocyte activity, phagocyte function,\u00a0leukocyte mobility, antibody and interferon production.<sup>1,2,3<\/sup>\u00a0In general, high doses of vitamin C need to be consumed daily in order to activate the immune system. Products containing small amounts of vitamin C provide little to no benefit to a person seeking an immediate immune response.<\/li>\n<li><strong>Echinacea<\/strong>\u00a0acts by activating many critical cells involved with a healthy immune response to infection, such as\u00a0neutrophils, macrophages, leukocytes, natural killer (NK) cells and other chemical messengers.<sup>4<\/sup><\/li>\n<li><strong>Elderberry<\/strong>\u00a0has several effects, including antiviral and immunomodulating effects, and it inhibits the replication of several strains of influenza viruses A and B,<sup>5<\/sup>\u00a0as well as H1N1 &#8220;swine&#8221; flu.<sup>6<\/sup>\u00a0It also increases the production of inflammatory cytokines, such as interleukins (ILs) and tumor necrosis factor (TNF).<sup>7<\/sup>\u00a0One of the unique properties of elderberry is it is a botanical extract offering both acute and long-term use benefits for immune health.<\/li>\n<li><strong>Zinc<\/strong>\u00a0is essential for neutrophil, NK cell and T-lymphocyte function.<sup>8<\/sup>\u00a0For acute use, zinc appears to be beneficial when used orally as a lozenge and taken frequently throughout the day\u2014not in one large dose, swallowed whole.<sup>9<\/sup><\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<h3>Long term<\/h3>\n<ul>\n<li><strong>Medicinal mushrooms<\/strong>\u00a0such as chaga, reishi, maitake, shitake and cordyceps impact lymphocytes, macrophages, T cells and NK cells.<sup>10<\/sup><\/li>\n<li><strong>1,3\/1,6<\/strong>\u00a0<strong>beta-glucan<\/strong>\u00a0increases macrophage phagocytosis of tumor cells, increases the cytotoxicity of NK cells and stimulates the release of IL-1 and TNF.<sup>11<\/sup><\/li>\n<li><strong>Probiotics<\/strong>\u00a0offer\u00a0beneficial impacts by different mechanisms, including their capacity to increase the intestinal barrier function, prevent pathogenic bacterial movement and modulate inflammation.<sup>12<\/sup>\u00a0Since an estimated 70% of the immune system originates in the gut,<sup>13<\/sup>\u00a0supporting the microbiome can play a positive role in immune health.<\/li>\n<li>In\u00a0numerous published clinical studies, low blood levels of\u00a0<strong>vitamin D<\/strong>\u00a0have been correlated\u00a0with an increased risk of infections.<sup>14<\/sup>\u00a0A secondary analysis of the Third National Health and Nutrition Examination Survey (NHANES) examined serum D levels of nearly 19,000 participants. The results suggested lower vitamin D levels were associated with higher episodes of self-reported upper respiratory tract infections (URTIs).<sup>15<\/sup>\u00a0For vitamin D to be beneficial, it is advisable to get vitamin D testing done to ensure the proper amounts are consumed.<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]<em>David Foreman is a registered pharmacist, author and media personality known to consumers internationally as \u201c<a href=\"http:\/\/herbalpharmacist.com\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">The Herbal Pharmacist<\/a>.\u201d A background in pharmacy and natural medicine puts him in an elite class of health experts who can teach integrative medicine practices. Foreman helps consumers achieve health and vitality through his four pillars of health: diet, exercise, spirituality and supplements. A graduate of the University of South Carolina College of Pharmacy, Foreman currently serves on the Organic &amp; Natural Health Association\u2019s (O&amp;N) scientific advisory board and is the author of \u201c4 Pillars of Health: Heart Disease.\u201d<\/em>[\/vc_column_text][vc_column_text]<strong>References<\/strong><\/p>\n<p>1 Leibovitz B, Siegel BV. \u201cAscorbic acid and the immune response.\u201d Adv Exp Med Biol. 1981;135:1-25.<\/p>\n<p>2 Vilter RW. \u201cNutritional aspects of ascorbic acid: uses and abuses.\u201d West J Med. 1980;133:485-492.<\/p>\n<p>3 Smogorzewska EM, Layward L, Soothill JF. \u201cT lymphocyte mobility: defects and effects of ascorbic acid, histamine, and complexed IgG.\u201d Clin.Exp.Immunol. 1981;43(1):174-179.<\/p>\n<p>4 Manayi A, Vazirian M, Saeidnia S. \u201cEchinacea purpurea: Pharmacology, phytochemistry, and analysis methods.\u201d Pharmacogn Rev. 2015;9(17):63-72.<\/p>\n<p>5 Zakay-Rones Z et al. \u201cInhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama.\u201d J Altern Complement Med. 1995;1:361-369.<\/p>\n<p>6 Roschek B et al. \u201cElderberry flavonoids bind to and prevent H1N1 infection in vitro.\u201d Phytochemistry. 2009;70:1255-1261.<\/p>\n<p>7 Barak V, Halperin T, Kalickman I. \u201cThe effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines.\u201d Eur Cytokine Netw. 2001;12:290-296.<\/p>\n<p>8 Shankar AH, Prasad AS. \u201cZinc and immune function: the biological basis of altered resistance to infection.\u201d Am J Clin Nutr. 1998;68:447S-463S.<\/p>\n<p>9 Mossad SB et al. \u201cZinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled study.\u201d Ann Intern Med. 1996;125:81-88.<\/p>\n<p>10 Guggenheim AG, Wright KM, Zwickey HL. \u201cImmune Modulation From Five Major Mushrooms: Application to Integrative Oncology.\u201d Integr Med (Encinitas). 2014;13(1):32-44.<\/p>\n<p>11 Stier H, Ebbeskotte V, Gruenwald J. \u201cImmune-modulatory effects of dietary Yeast Beta-1,3\/1,6-D-glucan.\u201d Nutr J. 2014;13:38 (2014).<\/p>\n<p>12 Plaza-D\u00edaz J et al. \u201cImmune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases.\u201d Nutrients. 2018;10(1):42.<\/p>\n<p>13 Vighi G et al. \u201cAllergy and the gastrointestinal system.\u201d Clin Exp Immunol. 2008;153(Suppl 1):3-6.<\/p>\n<p>14 Cannell JJ et al. \u201cEpidemic influenza and vitamin D.\u201d Epidemiol Infect. 2006;134(6):1129-1140.<\/p>\n<p>15 Ginde AA, Mansbach JM, Camargo Jr. CA. \u201cAssociation between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.\u201d Arch Intern Med. 2009;169(4):384-390.[\/vc_column_text][vc_column_text]Credit : <a href=\"http:\/\/www.naturalproductsinsider.com\">www.naturalproductsinsider.com<\/a>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Formulators can choose from a range of short-term and long-term ingredients when it comes to immune health support.<\/p>\n","protected":false},"author":1,"featured_media":5844,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - 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