{"id":5826,"date":"2021-04-30T16:09:48","date_gmt":"2021-04-30T09:09:48","guid":{"rendered":"https:\/\/www.primotrading.co.th\/?p=5826"},"modified":"2021-05-10T10:52:35","modified_gmt":"2021-05-10T03:52:35","slug":"15-ingredients-for-innovative-post-covid-supplement-formulations","status":"publish","type":"post","link":"https:\/\/www.primotrading.co.th\/th\/articles-th\/15-ingredients-for-innovative-post-covid-supplement-formulations\/","title":{"rendered":"15 ingredients for innovative post-COVID supplement formulations"},"content":{"rendered":"<p>[vc_row][vc_column][vc_custom_heading text=&#8221;15 ingredients for innovative post-COVID supplement formulations&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<strong>Consumers are clamoring for nutraceuticals to help with their immunity and general wellness. Boost your formulations with these evidence-based vitamins, minerals and specialty chemicals.<\/strong>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]In April 2020\u2014one year ago, and when COVID-19 was first sending shock waves throughout the world, market consultant giant\u00a0<a href=\"https:\/\/www.tricorbraun.com\/insights\/thought-leadership\/how-covid-19-accelerated-the-health-and-wellness-macrotrend\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">Accenture issued a report<\/a>\u00a0saying that even then, one of the top four consumer health and wellness trends was nutraceuticals.<\/p>\n<p>\u201cThe global pandemic,\u201d concluded the report, \u201chas created a huge surge in demand for everything wellness as consumers look to boost immune systems and improve overall physical and mental health.\u201d<\/p>\n<p>It noted ingredients from\u00a0<strong>melatonin<\/strong>\u00a0to\u00a0<strong>collagen<\/strong>,\u00a0<strong>essential oils<\/strong>\u00a0to\u00a0<strong>ginger<\/strong>\u00a0and\u00a0<strong>CBD<\/strong>.<\/p>\n<p>Other research studies show surprising benefit with plain ol\u2019 letter vitamins and select minerals. Basic nutrition stuff.[\/vc_column_text][vc_column_text]So it turns out that, as ever, the core natural products shopper\u2014and the overall marketplace from health food store retailers to supplement manufacturers, entrepreneurial food and beverage startups seeking to bring more health to more people to multinationals\u00a0looking to acquire the innovators\u2014was right.[\/vc_column_text][vc_column_text]Healthier food, better lifestyle practices and pursuits, improved nutrition\u2014and convenience and taste if you please\u2014are the way forward.[\/vc_column_text][vc_column_text]A slew of nutrition research studies has been published in the last year, specifically investigating baseline nutritional status and therapeutic dosage levels, and the results are really not too surprising to natural products insiders.[\/vc_column_text][vc_column_text]It also points the way to ingredients to integrate into immunity as well as general health formulations to pinpoint consumers\u2019 desires to use nutraceuticals in their quest for health and wellness in the age of coronaviruses.[\/vc_column_text][vc_column_text]<strong>Vitamin D<\/strong>\u00a0It might just be able to prevent, cure and treat COVID-19\u2014what is now called SARS-CoV-2\u2014despite the warning boxes on every supplement label per DSHEA saying supplements cannot \u201cprevent, cure of treat\u201d any disease. It is fairly unassailable at this point that vitamin D intake leads to improved outcomes, and higher baseline blood levels of vitamin D leads to better outcomes.\u00a0<a href=\"https:\/\/academic.oup.com\/jcem\/article\/106\/3\/e1343\/5934827\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">In one study<\/a>, 82.2% of hospitalized COVID patients had a vitamin D deficiency (defined at blood levels under 20 ng\/ml).[\/vc_column_text][vc_column_text]<a href=\"https:\/\/papers.ssrn.com\/sol3\/papers.cfm?abstract_id=3616008\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">One study showed<\/a>\u00a0those with deficiency levels (&lt;20 ng\/ml), compared with those of nicely high levels of &gt;55 ng\/ml were twice as likely to test positive for SARS-CoV-2\u2014prevention![\/vc_column_text][vc_column_text]<a href=\"https:\/\/www.mdpi.com\/2072-6643\/12\/9\/2757\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">Compared to those<\/a>\u00a0with levels north of 30 ng\/ml, those under that threshold had a 2- to 3-fold higher risk of dying, and double the chances of having a poor COVID outcome. And for those with acutely deficient levels below 12 ng\/ml, they had nearly 15 times a higher risk of dying and 6 times more likely to have a poor COVID outcome.[\/vc_column_text][vc_column_text]People with levels above 40 ng\/ml (the official cutoff of a deficiency is 20 ng\/ml) almost never get SARS-CoV-2.[\/vc_column_text][vc_column_text]\u201cWe definitely see a connection here,\u201d said Susan Hewlings, director of scientific affairs at ingredient supplier Nutrasource. \u201cWe have multiple mechanisms by which vitamin D can improve outcomes in COVID.\u201d[\/vc_column_text][vc_column_text]A total of 220 scientists and doctors issued\u00a0<a href=\"https:\/\/vitamindforall.org\/letter.html\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">an open letter<\/a>\u00a0to all governments, public health officials, doctors and healthcare workers calling for immediate widespread increased vitamin D intakes. Specifically, they find that 6,200 IU\/day is needed so that 97.5% of people to reach the 30 ng\/ml threshold. At bare minimum, the authors recommend adults take 4,000 IU\/day, which is widely regarded as safe. They recommend a loading dose of 10,000 IU\/day for two to three weeks.[\/vc_column_text][vc_column_text]They note that the scores of studies show<\/p>\n<ul>\n<li>Higher vitamin D blood levels are associated with lower rates of SARS-CoV-2 infection.<\/li>\n<li>Higher D levels are associated with lower risk of a severe case\u2014hospitalizations, ICU or death.<\/li>\n<li>Vitamin D\u2019s influence on COVID-19 is very likely causal, not just correlation.<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]\u201cThe preponderance of evidence indicates that increased vitamin D would help reduce infections, hospitalizations, ICU admissions and deaths,\u201d said the authors. \u201cThere is no need to wait for further clinical trials to increase use of something so safe, especially when remedying high rates of deficiency\/insufficiency should already be a priority.\u201d[\/vc_column_text][vc_column_text]\u201cNutritional research on nutrients is headlined by vitamin D3 and for good reason,\u201d said Michael Murray, N.D., co-author of the Encyclopedia of Natural Medicine, known as the bible for nutritional research. \u201cThose with science behind them become big sellers.\u201d[\/vc_column_text][vc_column_text]Murray pointed to clinical trial in process with vitamin D,<strong>\u00a0<\/strong>vitamin C, zinc, herbal medicines,<strong>\u00a0probiotics<\/strong>,<strong>\u00a0<\/strong>melatonin,\u00a0<strong>selenium\u00a0<\/strong>and quercetin\u2014sales of the flavonoid quercetin have doubled in the last year.[\/vc_column_text][vc_column_text]<strong>Quercetin<\/strong>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33034398\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">according to a study<\/a>, was ranked as the fifth best compound out of 18 candidates assessed to interfere with SARS-CoV-2 replication.[\/vc_column_text][vc_column_text]Researchers recommended that\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32636851\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">evidence supports quercetin<\/a>\u00a0being used with vitamin C because of overlapping antiviral and immunomodulatory properties, plus the capacity of vitamin C to recycle quercetin, increasing its efficacy.[\/vc_column_text][vc_column_text]The recommended dose is 1,000 mg\/day.<\/p>\n<p>And that\u2019s not all.[\/vc_column_text][vc_column_text]<strong>Magnesium<\/strong>\u00a0and vitamin K2 optimize vitamin D.\u00a0<a href=\"https:\/\/www.grassrootshealth.net\/blog\/supplemental-magnesium-important-vitamin-d-levels\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">One study found<\/a>\u00a0that people needed to take 146% more vitamin D to reach 40 ng\/ml than those who also took 400 mg\/day magnesium.<\/p>\n<p>\u201cMagnesium is needed to activate vitamin D,\u201d said James DiNicolantonio, Pharm.D., author of three health books and director of scientific affairs at ingredient supplier AIDP. \u201cMagnesium is the unsung hero that needs to activate the vitamin D.\u201d[\/vc_column_text][vc_column_text]<strong>Vitamin K2<\/strong>\u00a0also boosts D. The same study also found that 244% more vitamin D was needed to achieve 40 ng\/dl compared to those who supplemented with magnesium along with vitamin K2.[\/vc_column_text][vc_column_text]<a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.12.21.20248613v1\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">Another study<\/a>, in Denmark, found a correlation between serum vitamin K2 status and the severity of SARS-CoV-2 illness. \u201cOur study shows that low vitamin K status predicts mortality in patients with COVID-19,\u201d said the authors.[\/vc_column_text][vc_column_text]Among all menaquinones, menaquinone 7, or K2 MK-7, has the\u00a0<a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04770740?term=NCT04770740\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">best bioavailability and longest half-life<\/a>. \u201cBecause of their structural differences, vitamins K1 and K2 do not have the same biological activities,\u201d said Dr. Trygve Bergeland, VP Science at Kappa Bioscience AS, which supported new research into K2 and SARS-CoV-2. \u201cWith K2, the role of vitamin K extends beyond blood clotting, as it also regulates other important metabolic processes, such as calcification and inflammation. K1 is easily found in a balanced diet, which is not the case for K2. Deficiency might be more common than we think.\u201d[\/vc_column_text][vc_column_text]\u201cThere is a need for further experimental evidence to link vitamin K deficiency with the pathology of COVID-19 and determine whether vitamin K2 supplementation has a place in treatment protocols. The potential role of vitamin K2 supplementation to prevent development of severe COVID-19 in subjects who have not yet contracted COVID-19, but are at risk for the infection, is also very relevant to assess,\u201d Janssen concludes.[\/vc_column_text][vc_column_text]<strong>Zinc<\/strong>\u00a0is another mineral of note. It has had 17 studies on nearly 7,000 patients with COVID. Its efficacy against SARS-CoV-2 is about between vitamin D and vitamin C.[\/vc_column_text][vc_column_text]In all the studies, zinc had a 39% improvement. But so-called \u201cearly\u201d studies have better results\u2014giving interventions early on in a patients\u2019 diagnosis, versus other studies that give interventions as they are admitted to hospitals, or even late-stage studies where they are given interventions when things are looking pretty bleak.[\/vc_column_text][vc_column_text]In\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33122096\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">one provocative early study<\/a>, researchers tested interventions early on\u2014at four days after onset of COVID-19 symptoms. Researchers here combined zinc with the antibiotic azithromycin and the controversial hydroxychloroquine. It did find that the combination, compared to no treatment, led to about 80% decreased hospitalization and death among more than 500 patients.[\/vc_column_text][vc_column_text]\u201cThe optimal dose is 18 mg of ionic zinc,\u201d said DiNicolantonio. \u201cWhen you\u2019re sick, more than 75 mg\/day\u2014Cold-EEZE, two lozenges every two hours. Use\u00a0<strong>copper<\/strong>\u00a0with zinc because zinc can cause a copper deficiency\u20141 mg copper.\u201d[\/vc_column_text][vc_column_text]<strong>Vitamin C<\/strong>\u00a0also deserves a place on the podium of vitamins worthy of inclusion in any post-COVID formulation. The catch is that the research showing potential is all using ultra-high-dose intravenous vitamin C. Administering I.V. vitamin C obviously gets the ascorbic acid straight into the bloodstream, with bioavailability being close to 100%. (Bioavailability is defined as the degree to which the nutrient becomes available to the target tissue after it has been administered.)[\/vc_column_text][vc_column_text]However, supplementing with oral vitamin C, as with supplements, leads to decidedly lower absorption levels. According to the\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12134712\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">Institutes of Health<\/a>, vitamin C absorption is 70-90% when taken between doses of 30-180mg\/day. But when doses go above 1,000 mg\/day, absorption falls to less than 50%.[\/vc_column_text][vc_column_text]Do\u00a0<strong>bioflavonoids<\/strong>\u00a0help with vitamin C absorption? According to the\u00a0<a href=\"https:\/\/lpi.oregonstate.edu\/mic\/vitamins\/vitamin-C\/supplemental-forms\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">Linus Pauling Institute<\/a>\u00a0at Oregon State University, one study showed a 35% increase of vitamin C bioavailability with bioflavonoids, but three other studies showed no difference.[\/vc_column_text][vc_column_text]<a href=\"https:\/\/journals.sagepub.com\/doi\/10.4137\/NMI.S39764\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">Liposomal vitamin C<\/a>\u00a0has been shown to increase bioavailability by nearly 50% more than regular oral vitamin C but up to 5 times less than I.V. vitamin C.[\/vc_column_text][vc_column_text]Confirming the reports from small independent studies and 3 clinical trials, the\u00a0<a href=\"https:\/\/www.worldhealth.net\/news\/official-statement-china-recommended-treatment-covid-19\/\" target=\"_blank\" rel=\"noopener\" data-feathr-click-track=\"true\">Shanghai government has announced<\/a>\u00a0a recommendation to use high dose intravenous treatment of vitamin C to treat COVID-19. The dosage recommendation will vary with the severity of illness ranging from 50-200 milligrams per kilogram body weight (roughly 3.5-14g for an average-weight adult), administered via IV. Atsuo Yanagisawa, M.D., Ph.D. who is president of the Japanese College of Intravenous Therapy, states that this specific method of administration is very important because vitamin C\u2019s effects are at least 10 times more powerful when taken by IV rather than orally, and that \u201cIntravenous vitamin C is a safe, effective, and broad-spectrum antiviral.\u201d[\/vc_column_text][vc_column_text]Credit : <a href=\"http:\/\/www.naturalproductsinsider.com\">www.naturalproductsinsider.com<\/a>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Consumers are clamoring for nutraceuticals to help with their immunity and general wellness. Boost your formulations with these evidence-based vitamins, minerals and specialty chemicals.<\/p>\n","protected":false},"author":3,"featured_media":5827,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>15 ingredients for innovative post-COVID supplement formulations - Primo Trading Company Limited<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.primotrading.co.th\/articles\/15-ingredients-for-innovative-post-covid-supplement-formulations\/\" \/>\n<meta property=\"og:locale\" content=\"th_TH\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"15 ingredients for innovative post-COVID supplement formulations - Primo Trading Company Limited\" \/>\n<meta property=\"og:description\" content=\"Consumers are clamoring for nutraceuticals to help with their immunity and general wellness. 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