{"id":5091,"date":"2021-01-25T23:10:10","date_gmt":"2021-01-25T16:10:10","guid":{"rendered":"http:\/\/www.primotrading.co.th\/?p=5091"},"modified":"2021-01-25T23:10:10","modified_gmt":"2021-01-25T16:10:10","slug":"ingredients-of-interest-supporting-liver-function","status":"publish","type":"post","link":"https:\/\/www.primotrading.co.th\/th\/articles-th\/ingredients-of-interest-supporting-liver-function\/","title":{"rendered":"Ingredients of interest supporting liver function"},"content":{"rendered":"

[vc_row][vc_column][vc_custom_heading text=”Ingredients of interest supporting liver function”][vc_column_text]Do we really need nutraceuticals to support liver health? Experimental data, falling stars, risks and proven clinical benefits investigated.<\/strong>[\/vc_column_text][vc_column_text]The constant exposure of the liver to internal\u00a0and environmental harmful substances can overwhelm\u00a0its detoxification ability, causing a number of liver compromises. These range from hepatitis and non-alcoholic fatty liver disease (NAFLD), non-alcohol steatohepatitis (NASH)\u00a0to liver cirrhosis and hepatocellular carcinoma, while also presenting a risk\u00a0for other illnesss such as cardiovascular disease, strokes and diabetes.[\/vc_column_text][vc_column_text]As for liver support, there is a huge mass of empyrical data which has evolved from the\u00a0roots of Traditional Chinese Medicine (TCM) using a multitude of herbal ingredients, variably combined,\u00a0prepared or associated with other Chinese medicine. While these old origins certainly contain\u00a0pearls of wisdom, these solutions can hardly be assessed in modern medicine and, under no circumstance, can they be replicated nor advised\u00a0bona fide<\/em>. This is\u00a0because the\u00a0limitation of\u00a0trying to transfer old data from TCM to a modern, understandable and classifiable\u00a0setting resides in a lack\u00a0of knowledge of\u00a0TCM’s multimodal\u00a0mechanisms of action, as well as the detailed composition of all extracts.[\/vc_column_text][vc_column_text]The number of funtional foods, teas, vegetable oils, and herbal extracts offered over-the-counter with liver-supporting\u00a0claims, yet unapproved by health authorities, is countless, although some of these are backed by\u00a0published data. Several herbal compounds have been well studied on experimental level\u00a0in vitro<\/em>\u00a0or\u00a0in vivo<\/em>\u00a0but no clinical confirmation has ever been produced nor failed to confirm any significant benefit. This is the case of caffeine, tetrandrine, resveratrol, andrographolide, curcumin and\u00a0Salvia miltiorrhiza<\/em>\u00a0(red sage). Of course, one cannot rule out that some of the prior disappointing clinical studies suffered from methodological design or disorganised assessment.[\/vc_column_text][vc_column_text]In other cases, highly commercialised alleged ‘liver protectors,’\u00a0such as shisandra, have\u00a0been reported to raise lipid profile\u00a0side effects. Gamboge, a gum resin, has blurred its popularity after serious concerns were raised for its potential redox damage and inflammatory citokines balance. Some ginsenosides, extremely popular for their\u00a0range of health benefits, may require\u00a0careful attention. For eample, some ginsenosides may trigger drug hepatotoxicity by inhibiting cytochromes P450.[\/vc_column_text][vc_column_text]Two important Japanese compounds, glycyrrhyzin and sho-saiko-to,\u00a0have almost been abandoned; the first for its unsuitable intravenous administration and the second for\u00a0 severe side effects. A minor Japanese compound, YHK (China-imported mixture of panax pseudo-ginseng, Eucommia Ulmoides, polygonati rhizome and glycyrrhiza), has also not had any success\u00a0despite 10 years of basic science studies, which have disappeared from institutional hospital and clinics for\u00a0being unable to produce and publish any sound clinical data. In fact, it was recently shown at experimental level to be less efficient than an average antioxidant complex.[\/vc_column_text][vc_column_text]Berberine and sylimarin are somewhat good nutraceutical candidates, noted for safety. The former has\u00a0limited but promising clinical study support, while the latter is mostly used in western countries, although of TCM origin. The challenge of silymarin is that,\u00a0although\u00a0FDA-approved\u00a0to treat hepatotoxicity, there are multiple conflicting studies investingating\u00a0its robust significant effect\u00a0due to erratic pharmacokinetis and unpredictable absorption. Therefore, meta-analysis have assigned this ingredient an unclear indication.[\/vc_column_text][vc_column_text]Our group (ReGenera) studied a\u00a0promising novel hepatoprotector in a variety of liver diseases, such as NAFLD, NASH, alcohol-related hepatitis, viral hepatitis and drug-induced hapatitis. This is a most recent mixture obtained by a detailed high-technology powered extraction and purification, isolating the most functionally-active moieties. This phytomixture containing SBF-isolated effective components (oleanolic acid and saponins-rich ginsenosides, lignans, phenolics and steroids-rich eucommiaceae extracts and Alpha-OH-ursolic triterpene derivative) kinked to a glyco-carrier was tested in a large multicenter study with significant\u00a0benefits in liver profile and in epigenetic modulation of key genes for liver function.[\/vc_column_text][vc_column_text]In the quest for gaining ground for\u00a0clinical application, pharma-grade of natural plant selection, extraction and batch-to-batch control is\u00a0mandatory. Moreover, newer molecular biology techhnology now exists\u00a0to improve and deepen the scrutiny of the mechanisms of action and interaction of natural compounds. While old traditional medicine\u00a0maintain a source of ‘hints’ for the medical field, they need to be taken as an impulse to advance and finetune\u00a0modern and safe therapeutic solutions. The use of natural compounds, used either\u00a0alone or in adjunt to pharmacological treatment, do represent a fascinating opportunity in human health.[\/vc_column_text][vc_column_text]Francesco Marotta, M.D., Ph.D., is managing director at\u00a0ReGenera R&D International for Aging Intervention, Milano, Italy. Join Prof. Marotta and other experts in the digestive health panel discussion exploring new research supporting the gut as part of\u00a0Vitafoods Asia Digital Week.\u00a0<\/em>[\/vc_column_text][vc_column_text]Credit :\u00a0 www.vitafoodsinsights.com<\/a>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"

Do we really need nutraceuticals to support liver health? Experimental data, falling stars, risks and proven clinical benefits investigated.<\/p>\n","protected":false},"author":1,"featured_media":5092,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[20],"tags":[],"yoast_head":"\nIngredients of interest supporting liver function - Primo Trading Company Limited<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.primotrading.co.th\/th\/articles\/ingredients-of-interest-supporting-liver-function\/\" \/>\n<meta property=\"og:locale\" content=\"th_TH\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ingredients of interest supporting liver function - Primo Trading Company Limited\" \/>\n<meta property=\"og:description\" content=\"Do we really need nutraceuticals to support liver health? 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